Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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A Study of the Chemiluminescence Behavior of Cephalosporins with Luminol and Its Analytical Application

Author(s): Lichuan Niu, Zhenghua Song, Xili He.

Abstract:

The chemiluminescence intensity of luminol-dissolved oxygen was decreased when cephalosporins were mixed with luminol. The decrease chemiluminescence intensity was linear with the logarithm of cephalosporins concentration over the range from nanogram to microgramme level, with the limits of detection at nanogram level. The sensitivities of determination for cephalosporins were in the order of cefoperazone > ceftriaxone > cefuroxime > cefaclor > cefalexin > cefradine. The proposed method was applied to monitor the excretion of cefradine in human urine after taken cefradine capsules. The possible chemiluminescence mechanism and relationship between the determination sensitivities and generations of cephalosporins were also discussed.

Keywords: Chemiluminescence, cephalosporins, luminol, urine, serum, excretion

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2009
Page: [144 - 151]
Pages: 8
DOI: 10.2174/187231209789352157
Price: $58