Leptin as Clinical Target
Chunlin Cai, Fu-Dong Shi, Giuseppe Matarese and Antonio La Cava
Affiliation: Department of Medicine at the University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, California 90095-1670, USA.
Leptin is an adipocyte-derived hormone with pleiotropic effects on energy homeostasis, endocrine and reproductive functions, and immune responses. The multiple actions of leptin have led to the design and development of several leptin-based approaches to modulate the metabolic and endocrine status, to reduce inflammation, and to improve immune responses. Here, we review the current patents on leptin in different clinic applications.
Keywords: Leptin, metabolism, therapeutics
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