Cerebrovascular Diseases in HIV-Infected Patients

Author(s): Jean-Jacques Monsuez, Colette Goujon, Benjamin Wyplosz, Carine Couzigou, Lelia Escaut, Daniel Vittecoq.

Journal Name: Current HIV Research

Volume 7 , Issue 5 , 2009

Become EABM
Become Reviewer

Abstract:

Cerebrovascular disease (CVD) has early been recognized in HIV-infected patients, including infectious arteritis, inflammatory vasculitis, aneurismal and small-vessel arteriopathy, to which adds now the premature atherosclerotic cerebral arteriopathy associated with the highly active antiretroviral therapy (HAART)-induced metabolic disorders. As a result of the increased life-expectancy associated with HAART, HIV patients grow older and are exposed to the combined vascular risk of antiviral-induced metabolic changes and advancing age. Several studies have documented subclinical cervical artery atherosclerosis, as assessed by intima-media thickness, ultrasound detection of carotid artery plaques and intracerebral small-vessel disease, all being associated with the induced metabolic changes. This suggests that vascular prevention should be performed on a long-term basis.

Keywords: HIV, AIDS, Stroke, Cerebrovascular disease

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 7
ISSUE: 5
Year: 2009
Page: [475 - 480]
Pages: 6
DOI: 10.2174/157016209789346345
Price: $58

Article Metrics

PDF: 8