Abstract
Members of the viral family Flaviviridae are a major cause of infectious diseases, such as hepatitis C, Dengue fever, Japanese encephalitis, Yellow fever or West Nile fever. Major efforts are therefore being made to identify medicines that can fight these infections. The genome of the Flaviviridae contains a single ORF that is translated into a precursor polyprotein which is processed in the host into several proteins. Amongst these, the nonstructural protein 3 (NS3) is formed from two domains that show distinct catalytic activities: a serine protease and a helicase activity. Since both activities are required for viral replication, there is a lot of interest in investigating NS3 as a potential drug target. On the basis of the structural information available, we shall assess here the druggability of the helicase domain of NS3.
Keywords: NS3 helicase, hepatitis C virus, dengue virus, west nile virus
Current Chemical Biology
Title: NS3 Helicases as Drug Targets
Volume: 3 Issue: 3
Author(s): Patrick Chene
Affiliation:
Keywords: NS3 helicase, hepatitis C virus, dengue virus, west nile virus
Abstract: Members of the viral family Flaviviridae are a major cause of infectious diseases, such as hepatitis C, Dengue fever, Japanese encephalitis, Yellow fever or West Nile fever. Major efforts are therefore being made to identify medicines that can fight these infections. The genome of the Flaviviridae contains a single ORF that is translated into a precursor polyprotein which is processed in the host into several proteins. Amongst these, the nonstructural protein 3 (NS3) is formed from two domains that show distinct catalytic activities: a serine protease and a helicase activity. Since both activities are required for viral replication, there is a lot of interest in investigating NS3 as a potential drug target. On the basis of the structural information available, we shall assess here the druggability of the helicase domain of NS3.
Export Options
About this article
Cite this article as:
Chene Patrick, NS3 Helicases as Drug Targets, Current Chemical Biology 2009; 3 (3) . https://dx.doi.org/10.2174/2212796810903030334
DOI https://dx.doi.org/10.2174/2212796810903030334 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Invasion and Egress by the Obligate Intracellular Parasite Toxoplasma gondii: Potential Targets for the Development of New Antiparasitic Drugs
Current Pharmaceutical Design Immunization for Persons Infected with Human Immunodeficiency Virus
Current HIV Research DNA Microarrays - An Armory for Combating Infectious Diseases in the New Century
Infectious Disorders - Drug Targets The Central Role of Angiotensin I-Converting Enzyme in Vertebrate Pathophysiology
Current Topics in Medicinal Chemistry The Role of Microbial Agents in the Etiology of Schizophrenia: An Infectious Hypothesis for Psychosis?
Current Immunology Reviews (Discontinued) Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research Current Opinions and Perspectives on the Role of Immune System in the Pathogenesis of Parkinson's Disease
Current Pharmaceutical Design The Role of Inflammation in Epilepsy
Current Pediatric Reviews Virus-Based RNA Silencing Agents and Virus-Derived Expression Vectors as Gene Therapy Vehicles
Recent Patents on Biotechnology The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain
Current Neuropharmacology The Use of Oncolytic Vaccinia Viruses in the Treatment of Cancer: A New Role for an Old Ally?
Current Gene Therapy Biological Activity of Cytokines: An Evolutionary Perspective
Current Pharmaceutical Design Commentary: (Research Highlights Inflammation, Demyelination and Neurodegeneration: Risky Buddies in Multiple Sclerosis)
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic: Innate Immunity and Autoimmune Disease (Guest Editors: F. Susan Wong and Li Wen)]
Current Molecular Medicine Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)
Recent Patents on Anti-Infective Drug Discovery Microneedle Patches as Drug and Vaccine Delivery Platform
Current Medicinal Chemistry Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics
Current Topics in Medicinal Chemistry Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Virus, Oncolytic Virus and Human Prostate Cancer
Current Cancer Drug Targets Reporting Rates of Yellow Fever Vaccine 17D or 17DD-Associated Serious Adverse Events in Pharmacovigilance Data Bases: Systematic Review
Current Drug Safety