A Comparative Study on the Stability of Silybin and That in Silymarin in Buffers and Biological Fluids

Title: A Comparative Study on the Stability of Silybin and That in Silymarin in Buffers and Biological Fluids

Volume: 3 Issue: 2

Author(s): Ning Tang, Danni Wu, Yi Lu, Jian Chen, Bei Zhang and Wei Wu

Affiliation:

Keywords: Stability, silybin, silymarin, buffer, biological fluid, synergy

Abstract: Pure silybin was found to be unstable whilst silybin in silymarin was stable in buffers from pH 1.0 to 7.8. The metabolism of silybin was more severe when in its pure form as compared to silybin in silymarin, as tested in a range of biological fluids including plasma, intestinal fluid and liver homogenates. It would appear that components in silymarin have a stabilization effect on its main component silybin.

Cite this article as:

Tang Ning, Wu Danni, Lu Yi, Chen Jian, Zhang Bei and Wu Wei, A Comparative Study on the Stability of Silybin and That in Silymarin in Buffers and Biological Fluids, Drug Metabolism Letters 2009; 3 (2) . https://dx.doi.org/10.2174/187231209788654072