Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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A Comparative Study on the Stability of Silybin and That in Silymarin in Buffers and Biological Fluids

Author(s): Ning Tang, Danni Wu, Yi Lu, Jian Chen, Bei Zhang, Wei Wu.

Abstract:

Pure silybin was found to be unstable whilst silybin in silymarin was stable in buffers from pH 1.0 to 7.8. The metabolism of silybin was more severe when in its pure form as compared to silybin in silymarin, as tested in a range of biological fluids including plasma, intestinal fluid and liver homogenates. It would appear that components in silymarin have a stabilization effect on its main component silybin.

Keywords: Stability, silybin, silymarin, buffer, biological fluid, synergy

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2009
Page: [115 - 119]
Pages: 5
DOI: 10.2174/187231209788654072
Price: $58