Differences in Lopinavir Plasma Concentrations Comparing Kaletra® Film Coated Tablets and Soft Gelatine Capsules That Result in Various Lipid Abnormalities

Author(s): Judit Morello, Vincent Soriano, Francisco Blanco, Antonio J. Rubio, Inmaculada Jimenez-Nacher, Sonia Rodriguez-Novoa.

Journal Name: Drug Metabolism Letters

Volume 3 , Issue 2 , 2009

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Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.

Keywords: Lopinavir, pharmacokinetics, metabolic complications, dislipidemia, cardiovascular risk, HIV

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Article Details

Year: 2009
Page: [67 - 69]
Pages: 3
DOI: 10.2174/187231209788654036
Price: $58

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