Differences in Lopinavir Plasma Concentrations Comparing Kaletra® Film Coated Tablets and Soft Gelatine Capsules That Result in Various Lipid Abnormalities
Antonio J. Rubio,
Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.
Keywords: Lopinavir, pharmacokinetics, metabolic complications, dislipidemia, cardiovascular risk, HIV
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