EGFR Expression Correlates with Maximum Standardized Uptake Value of 18F- fluorodeoxyglucose-PET in Squamous Cell Lung Carcinoma

Author(s): Ihab Abdulkader, Alvaro Ruibal, Jose Cameselle-Teijeiro, Francisco Gude, Luis Leon, Patricia Arce-Calisaya, Aida Sanchez-Salmon, Jeronimo Forteza.

Journal Name: Current Radiopharmaceuticals

Volume 2 , Issue 3 , 2009

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Abstract:

EGFR, an oncogenic tyrosine kinase receptor, is a relevant target for anti-cancer therapies; survival of cancer cells however, is also maintained by EGFR regardless of its kinase activity. In tumor cells EGFR prevents autophagic cell death by maintaining the intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1). Since this function of EGFR directly impacts on glucose uptake, positron emission tomography (PET) scans would be a useful biomarker for therapy aimed toward inhibiting the binding of EGFR to SGLT1. Here, we analyzed the possible relationship between the immunoexpression of EGFR in patients with squamous cell lung cancer and the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose-PET. Membranous immunostaining for EGFR was positive in all patients, and a correlation between EGFR expression and SUVmax was observed (p < 0.05). Therefore, we can conclude that EGFR expression is a common event associated with squamous cell lung carcinomas that positively correlates with SUVmax.

Keywords: EGFR, positron emission tomography, squamous cell lung cancer

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2009
Page: [175 - 176]
Pages: 2
DOI: 10.2174/1874471010902030175
Price: $58

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