Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction
Channa N. Jayasena, George Tharakan and Waljit S. Dhillo
Affiliation: Department of Investigative Medicine, 6th Floor, Commonwealth Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN.
Dysfunction of the hypothalamo-pituitary gonadal (HPG) axis may result in a variety of disorders, ranging from precocious puberty to infertility. Current therapies for such disorders have varying degrees of success, and are associated with adverse effects and / or practical limitations. The recent identification of Kisspeptin as a critical regulator of reproduction, may offer a new avenue for therapeutically manipulating the HPG axis. This article provides a synopsis of the role of Kisspeptin and the Kisspeptin receptor in reproduction, with an emphasis on potential areas of its exploitation as a therapeutic or diagnostic tool. This article also reviews some of the recent patents related to the field.
Keywords: Kisspeptin, metastin, GPR54, gonadotrophin, infertility, hypothalamus, GnRH
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