Abstract
Mother-to-child transmission during pregnancy provides a unique system for studying the correlation between HLA phenotype and susceptibility to HIV infection. We studied this relationship in a Spanish cohort. We determined frequencies of HLA class I and II alleles in 120 infants born to HIV-infected mothers and 67 HIV-infected mothers. Although there was no statistical difference in the frequency of HLA-B35 between transmitting and non-transmitting mothers, the allele was more frequent in infected children than in uninfected children. HLA-B35 has been consistently reported as a risk factor in the progression to AIDS. In addition, it has been proposed that whether a given allele can confer susceptibility to, or protection against, progression depends on maternal versus paternal inheritance patterns, since the child inherits a virus that reflects the history of CTL encounters of the mother. Our results on vertical HIV transmission combine for the first time the ‘HLA-B35 disadvantage’ and the ‘pattern of inheritance’ theories.
Keywords: HLA disadvantage, HIV vertical infection, Major Histocompatibility complex, pattern of inheritance, progression to AIDS
Current HIV Research
Title: Risk of Vertical HIV Transmission Combines the ‘B35-Cw4 Disadvantage’ and the ‘Pattern of Inheritance’ Theories of Progression
Volume: 7 Issue: 3
Author(s): Antonio Arnaiz-Villena, Jose Manuel Martin-Villa, Jose Tomas Ramos Amador, Almudena Cendoya-Matamoros, Maria Isabel Gonzalez Tome, Jose Maria Rivera and Narcisa Martinez-Quiles
Affiliation:
Keywords: HLA disadvantage, HIV vertical infection, Major Histocompatibility complex, pattern of inheritance, progression to AIDS
Abstract: Mother-to-child transmission during pregnancy provides a unique system for studying the correlation between HLA phenotype and susceptibility to HIV infection. We studied this relationship in a Spanish cohort. We determined frequencies of HLA class I and II alleles in 120 infants born to HIV-infected mothers and 67 HIV-infected mothers. Although there was no statistical difference in the frequency of HLA-B35 between transmitting and non-transmitting mothers, the allele was more frequent in infected children than in uninfected children. HLA-B35 has been consistently reported as a risk factor in the progression to AIDS. In addition, it has been proposed that whether a given allele can confer susceptibility to, or protection against, progression depends on maternal versus paternal inheritance patterns, since the child inherits a virus that reflects the history of CTL encounters of the mother. Our results on vertical HIV transmission combine for the first time the ‘HLA-B35 disadvantage’ and the ‘pattern of inheritance’ theories.
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Arnaiz-Villena Antonio, Martin-Villa Manuel Jose, Amador Tomas Ramos Jose, Cendoya-Matamoros Almudena, Tome Isabel Gonzalez Maria, Rivera Maria Jose and Martinez-Quiles Narcisa, Risk of Vertical HIV Transmission Combines the ‘B35-Cw4 Disadvantage’ and the ‘Pattern of Inheritance’ Theories of Progression, Current HIV Research 2009; 7 (3) . https://dx.doi.org/10.2174/157016209788348029
DOI https://dx.doi.org/10.2174/157016209788348029 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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