Recent Patents on DNA & Gene Sequences

Christian Bronner  
Institute of Genetics and Molecular and Cellular Biology
University of Strasboug
France

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Recent Patents and Patent Applications Relating to mTOR Pathway

Author(s): Xiangyu Liu and Zhenyu Yue

Affiliation: Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

Keywords: mTOR, mTORC1, mTORC2, rapamycin, Akt/PKB, S6K, 4EBP1, TSC1/TSC2, Rheb, cancer

Abstract:

The mammalian target of rapamycin (mTOR) plays an important role in cell growth. Dysfunction of mTOR has been linked to many human diseases, such as cancers, obesity, diabetes, cardiovascular diseases and neurological disorders. Currently, the mTOR inhibitor rapamycin and its analogs have been vigorously evaluated and developed as anticancer drugs. Here, we will review the most recent patents and patent applications relating to mTOR pathway. Moreover, we will discuss the patents and patent applications on the treatment of mTOR-associated metabolic diseases and cancers.

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Article Details

VOLUME: 3
ISSUE: 1
Page: [44 - 52]
Pages: 9
DOI: 10.2174/187221509787236192