Recent Patents on Biotechnology

Rongling Wu
Departments of Public Health Sciences and Statistics
Pennsylvania State College of Medicine
Hershey, PA


Baculovirus Expression Systems for Recombinant Protein Production in Insect Cells

Author(s): Richard B. Hitchman, Robert D. Possee and Linda A. King

Affiliation: Oxford Expression Technologies Ltd, Oxford Brookes University, Oxford OX3 0BP, UK.


Baculoviruses are lethal pathogens of insects, predominantly of the order Lepidoptera. These viruses have a biphasic life cycle, which greatly facilitates their use for biotechnological applications. They were exploited initially as biocontrol agents, and then engineered as protein expression vectors. The baculovirus expression vector system (BEVS) is now widely used for recombinant protein production. More recently they have become a popular choice for development as gene delivery and expression vectors in mammalian cells. This article reviews some of the major developments and patents relating to baculoviruses since their initial use as an expression tool and investigates current technologies alleviating bottlenecks in recombinant gene expression in insect cells.

Keywords: Baculovirus, budded virus, bacmid, high throughput and recombinant protein expression

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Article Details

Page: [46 - 54]
Pages: 9
DOI: 10.2174/187220809787172669