Production and Application of Bacteriophage and Bacteriophage-Encoded Lysins
Noemie M. Dorval Courchesne, Albert Parisien and Christopher Q. Lan
Affiliation: Department of Chemical and Biological Engineering, The University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Keywords: Virolysin, antibiotic resistance, lytic enzyme, lysin, bacteriophage
The widespread resistance to antibiotics among pathogenic bacteria has made development of alternatives to antibiotics a pressing public concern. Extensive studies have established bacteriophages (phages) and phage-encoded lytic enzymes (virolysins) as two of the most promising families of alternative antibacterials for the treatment and prophylaxis of bacterial infections. They have shown great potential in veterinary and human medicine for the treatment and prophylaxis of infections. Technologies have also been patented employing phages and virolysins in other pathogen related applications including detection and decontamination.
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