Study of Efficacy of Reactivator HI-6 in Reactivation of Immobilized Acetylcholinesterase, Inhibited by Organophosphorus Chemical Warfare Agents of the “G” Series

Author(s): Monika Hoskovcova, Emil Halamek, Zbynek Kobliha.

Journal Name: Drug Metabolism Letters

Volume 3 , Issue 1 , 2009

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Reactivation with bis-quaternary aldoxime HI-6, chemical formula 1-(2-hydroxyaminomethylpyridinium)-3-(4- carbamoylpyridinium)-2-oxapropane dichloride of immobilized enzyme acetylcholinesterase inhibited by nerve agent type “G” was studied. This aldoxime is effective in reactivation of sarin-inhibited acetylcholinesterase. Substantially lower reactivation potency was observed with cyclosarin-inhibited enzyme and almost no effect was found for that acetylcholinesterase is the enzyme complex. HI-6 is completely ineffective towards the soman-inhibited enzyme: After a 2-minute inhibition of the enzyme with soman no ability to define reactivator the inhibited enzymes and complexes.

Keywords: Acetylcholinesterase, biosensors, enzyme inhibitors, enzyme reactivation, HI-6, organophosphorus warfare agents

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Article Details

Year: 2009
Page: [54 - 57]
Pages: 4
DOI: 10.2174/187231209787176380

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