Study of Efficacy of Reactivator HI-6 in Reactivation of Immobilized Acetylcholinesterase, Inhibited by Organophosphorus Chemical Warfare Agents of the “G” Series
Reactivation with bis-quaternary aldoxime HI-6, chemical formula 1-(2-hydroxyaminomethylpyridinium)-3-(4- carbamoylpyridinium)-2-oxapropane dichloride of immobilized enzyme acetylcholinesterase inhibited by nerve agent type “G” was studied. This aldoxime is effective in reactivation of sarin-inhibited acetylcholinesterase. Substantially lower reactivation potency was observed with cyclosarin-inhibited enzyme and almost no effect was found for that acetylcholinesterase is the enzyme complex. HI-6 is completely ineffective towards the soman-inhibited enzyme: After a 2-minute inhibition of the enzyme with soman no ability to define reactivator the inhibited enzymes and complexes.
Keywords: Acetylcholinesterase, biosensors, enzyme inhibitors, enzyme reactivation, HI-6, organophosphorus warfare agents
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