Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport

Author(s): Yuan Cao, Xinyong Liu, Erik De Clercq.

Journal Name: Current HIV Research

Volume 7 , Issue 1 , 2009

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Abstract:

The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.

Keywords: AIDS, HIV-1, transcription, inhibitors, Rev, RRE, antiviral

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2009
Page: [101 - 108]
Pages: 8
DOI: 10.2174/157016209787048564

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