IL-2, IL-7 and IL-15 as Immuno-Modulators During SIV/HIV Vaccination and Treatment

Author(s): Amanda Leone, Louis J. Picker, Donald L. Sodora.

Journal Name: Current HIV Research

Volume 7 , Issue 1 , 2009

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Abstract:

While highly active antiretroviral therapy (HAART) regimens have proven to be effective in controlling active HIV replication, complete recovery of CD4+ T cells does not always occur, even among patients with high level virologic control. Recent advances in understanding the biology of T cell production and homeostasis have created the potential to augment anti-viral therapies with immunotherapies designed to facilitate recovery of the HIV-damaged immune system, in particular, the recovery of CD4+ T cell populations. The common gamma-chain cytokines IL-2, IL-7 and IL-15 are primary regulators of T cell homeostasis and thus have been considered prime candidate immunotherapeutics, both for increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. Recent studies have established that these cytokines have distinct functional roles in immune homeostasis, which focus on specific T cell populations. The ability of these cytokines to provide immunotherapeutic benefit to HIV+ patients will depend on their ability to stably increase or functionally enhance the desired T cell target population without adverse virologic or clinical consequences.

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2009
Page: [83 - 90]
Pages: 8
DOI: 10.2174/157016209787048519

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