Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability

Author(s): Karel Allegaert, Isabelle Scheers, Veerle Cossey, Brian J. Anderson.

Abstract:

An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.

Keywords: Ontogeny, renal drug clearance, amikacin, covariates, predictability

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2008
Page: [286 - 289]
Pages: 4
DOI: 10.2174/187231208786734157
Price: $58