Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability
Brian J. Anderson.
An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.
Keywords: Ontogeny, renal drug clearance, amikacin, covariates, predictability
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