Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Identification of Four Urea Adducts of Andrographolide in Humans

Author(s): Liang Cui, Wan Chan, Feng Qiu, Zongwei Cai, Xinsheng Yao.

Abstract:

Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Keywords: Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2008
Page: [261 - 268]
Pages: 8
DOI: 10.2174/187231208786734148
Price: $58