Identification of Four Urea Adducts of Andrographolide in Humans
Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.
Keywords: Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS
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