Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors

Author(s): C.H. T.P. da Silva, V.B. da Silva, C. A. Taft.

Abstract:

Virtual screening docking-based approach has been employed in order to select novel HIV-1 integrase (IN) potential inhibitors in large databases. Toxicity, metabolism and drug-like properties have been analyzed for the most promising compounds, using computational chemistry techniques. Results were compared and discussed with that obtained for a known HIV-1 (IN) inhibitor reported in the literature.

Keywords: Pharmacodynamic, HIV-1 Integrase Inhibitors, Virtual screening, metabolism, computational chemistry

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2008
Page: [256 - 260]
Pages: 5
DOI: 10.2174/187231208786734102
Price: $58