Current HIV Research

Charles Wood  
University of Nebraska
Lincoln, NE


NK Cell Function in HIV-1 Infection

Author(s): Andrea De Maria and Lorenzo Moretta

Affiliation: S.S. Infettivologia, Istituto Nazionale per la Ricerca sul Cancro, Largo R.Benzi 10, 16132 Genova, Italy.


The parallel development of precise knowledge on NK cell receptors and on their function has considerably supported our understanding of the extension of their involvement during HIV-1 infection. The relevant reduction of NK cell function is dependent on well-described perturbations of their expression of specific receptors, leading not only to inhibition of their patrolling activity against invading pathogens, but also to alterations of their crosstalk with other cells of the immune system. With NK cell failure, boosted viral replication reduces immune surveillance towards opportunistic neoplasm and impaired control of adaptive responses prevails. NK cell function in human and animal models showing efficient control of disease progression may offer new insights in mechanisms underlying the protection from infectious disease.

Keywords: NK cell, HIV-1, natural cytotoxicity receptor, dendritic cells

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Article Details

Page: [433 - 440]
Pages: 8
DOI: 10.2174/157016208785861221
Price: $58