Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Author(s): Adukamparai R.S. Babu , Raghavachary Raghunathan , Narayanasamy Mathivanan , Gurusamy Omprabhac , Devadasan Velmurugan , Rangasamy Raghu .

Journal Name: Current Chemical Biology

Volume 2 , Issue 3 , 2008

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Abstract:

A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispiro-oxindolopyrrolidines are correlated with the docking calculations performed on protein S12 from 30S ribosomal subunit.

Keywords: 1,3-Dipolar cycloaddition, azomethine ylide, spiro-pyrrolidines, spiro-oxindolopyrrolidine, anti-microbial activity, 30S ribosomal subunit

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2008
Page: [312 - 320]
Pages: 9
DOI: 10.2174/2212796810802030312
Price: $58

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