Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS
James F. Rusling.
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.
Keywords: Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole
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