Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS

Author(s): Besnik Bajrami, Sadagopan Krishnan, James F. Rusling.

Abstract:

Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N -nitro so compounds.Using these biocolloids,turnover rates were measured within 2 min. Inhibitor IC 50 values for ketoconazole(KET) and 4-methylpyrazoie (4-MEP) were estimated.

Keywords: Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2008
Page: [158 - 162]
Pages: 5
DOI: 10.2174/187231208785425854
Price: $58