Interactions of β - and Hydroxypropyl-β-Cyclodextrin with Some Purine Alkaloids:Thermodynamic Study

Author(s): Irina V. Terekhova.

Journal Name: Current Drug Discovery Technologies

Volume 5 , Issue 2 , 2008

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Abstract:

The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between β-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that β-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both β-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and β-cyclodextrin on the thermodynamic parameters of interaction was discussed.

Keywords: Cyclodextrin, xanthines, solubility, calorimetry, thermodynamics of interactions

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [168 - 172]
Pages: 5
DOI: 10.2174/157016308784746201
Price: $58

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