Inflammation is a group of important pathological disorders in medicine. The main classical hallmarks for inflammation are pain, swelling and heat. Basically, there are two main groups of anti-inflammation drug, the steroid antiinflammation drug and non steroid anti-inflammation drug, which is widely called NSAIDS. At present, there are many new anti-inflammatory drugs. Those new anti-inflammatory drugs are developed expecting for the better pharmacological reaction. In this article, the author will briefly review on the patents on new topical anti-inflammatory drug.