Recent Patents on Chemical Engineering

Yousheng Tao  
State Key Laboratory of Structural Chemistry
Fujian Institute of Research on the Structure of Matter
Chinese Academy of Sciences


Membranes in the Downstream Processing of Biotech Manufactured Drugs

Author(s): Anthony Allegrezza

Affiliation: 80 Ashby Road, Bedford MA 01730 USA.


This review covers synthetic membranes used in the downstream (post fermenter) processing of biotherapeutic proteins manufactured in the biotechnology industry. Biotherapeutics are very expensive proteins, made in gram per liter quantities, in a highly regulated industry. Microfiltration, ultrafiltration, virus removal and adsorption membranes separate and purify the product proteins in the several process steps between the fermenter and the final filled vial. Patent activity for these specialized membranes, primarily in 2006-2007, was reviewed for new membrane development and for novel processes using these membranes.

Keywords: Microfiltration, microfilters, microporous, membrane, ultrafilters, ultrafiltration, monoclonal antibodies, virus, separation, purification

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Article Details

Page: [106 - 112]
Pages: 7
DOI: 10.2174/2211334710801020106