Abstract
Metal complexes of amino acids or small peptides interest biochemists. Some studies about their structures have therefore been carried out on the assumption that such complexes will act as models for the metal-binding sites on proteins. From the point of view of coordination chemistry, an amino acid can be regarded as a typical multidentate ligand which has different ligating atoms, a nitrogen atom of an amino group and an oxygen atom of a carboxyl group. The different ligating atoms can be coordinated to different metal ions such as metals having different hardness. The advantages of amino acid of being able to form a chelate ring and/or be coordinated to different metals can be used to synthesize heteronuclear and/or polynuclear complexes. Such syntheses of heteronuclear and/or polynuclear complexes continue to be an intensive and challenging area of investigation. In this article, some examples of polynuclear complexes with amino acids or peptides as a bridging ligand will be introduced and the possibility of using amino acidato complexes as potential building blocks in the formation of more complicated polynuclear arrays will be explored.
Keywords: Amino acid, peptide, polynuclear complex, X-ray structure
Current Chemical Biology
Title: Synthesis of Polynuclear Complexes with an Amino Acid or a Peptide as a Bridging Ligand
Volume: 2 Issue: 2
Author(s): Takashi Komiyama, Satoshi Igarashi and Yasuhiko Yukawa
Affiliation:
Keywords: Amino acid, peptide, polynuclear complex, X-ray structure
Abstract: Metal complexes of amino acids or small peptides interest biochemists. Some studies about their structures have therefore been carried out on the assumption that such complexes will act as models for the metal-binding sites on proteins. From the point of view of coordination chemistry, an amino acid can be regarded as a typical multidentate ligand which has different ligating atoms, a nitrogen atom of an amino group and an oxygen atom of a carboxyl group. The different ligating atoms can be coordinated to different metal ions such as metals having different hardness. The advantages of amino acid of being able to form a chelate ring and/or be coordinated to different metals can be used to synthesize heteronuclear and/or polynuclear complexes. Such syntheses of heteronuclear and/or polynuclear complexes continue to be an intensive and challenging area of investigation. In this article, some examples of polynuclear complexes with amino acids or peptides as a bridging ligand will be introduced and the possibility of using amino acidato complexes as potential building blocks in the formation of more complicated polynuclear arrays will be explored.
Export Options
About this article
Cite this article as:
Komiyama Takashi, Igarashi Satoshi and Yukawa Yasuhiko, Synthesis of Polynuclear Complexes with an Amino Acid or a Peptide as a Bridging Ligand, Current Chemical Biology 2008; 2 (2) . https://dx.doi.org/10.2174/2212796810802020122
DOI https://dx.doi.org/10.2174/2212796810802020122 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
2-Mercaptobenzothiazole and its Derivatives: Syntheses, Reactions and Applications
Current Organic Chemistry Cationic Liposomes as Non-viral Vector for RNA Delivery in Cancer Immunotherapy
Recent Patents on Drug Delivery & Formulation Effect of Number of Bifunctional Chelating Agents on the Pharmacokinetics and Immunoreactivity of 177Lu-labeled Rituximab: A Systemic Study
Anti-Cancer Agents in Medicinal Chemistry Novel Hydroxamate and Anilide Derivatives as Potent Histone Deacetylase Inhibitors: Synthesis and Antiproliferative Evaluation
Current Medicinal Chemistry Secondary Structure of the Homologous Proteins, A A-Fetoprotein and Serum Albumin, from their Circular Dichroism and Infrared Spectra
Protein & Peptide Letters Identification of Flavonoids by LC-MS/MS in Leaves Extract From <i>Protium heptaphyllum</i> (Aubl.) March and Antioxidant Activity in Mice
The Natural Products Journal Phenolic Contents and Antioxidant Activity of Helicteres Hirsuta Extracts
Letters in Organic Chemistry Risk-Benefit Perspectives in COX-2 Blockade
Current Drug Safety Arsenic Trioxide and Artemisinin Act Synergistically to Kill Tumor Cells In Vitro
Anti-Cancer Agents in Medicinal Chemistry Optimal Control for Generalized Asynchronous Probabilistic Boolean Networks †
Current Bioinformatics Modulation of Stem Cell Differentiation by the Influence of Nanobiomaterials/ Carriers
Current Stem Cell Research & Therapy Synthesis and Biological Evaluation of 2-thiazolylimino-5-arylidene-4- thiazolidinone Derivatives as Potent Antimycobacterial Agents
Anti-Infective Agents Application of Solvent Influenced Fluorescence-quenching and Enhancement to Develop a Highly Sensitive HPLC Methodology for Analysis of Resveratrol-PEG Conjugates
Current Pharmaceutical Analysis Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing
Medicinal Chemistry Meet Our Editorial Board Member
Current Proteomics Microfluidic Hydrodynamic Cell Separation: A Review
Micro and Nanosystems Live Impedance Measurements and Time-lapse Microscopy Observations of Cellular Adhesion, Proliferation and Migration after Ionizing Radiation
Current Pharmaceutical Biotechnology Recent Patents of Nanodevices for Single Cell Immunological Assays
Recent Patents on Nanotechnology Review on Digital Breast Tomosynthesis Patents
Recent Patents on Biomedical Engineering (Discontinued) Metal-dithiocarbamate complexes: chemistry and biological activity
Mini-Reviews in Medicinal Chemistry