Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

Author(s): Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen, Rolf K. Berge.

Abstract:

Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2008
Page: [138 - 145]
Pages: 8
DOI: 10.2174/187231208784041013