Effect of Folic Acid on Methotrexate Induction of Sulfotransferases in Rats
Sangita Maiti Dutta,
Our earlier investigation showed that MTX is an inducer of rat and human sulfotransferases. Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver. This is important for understanding the clinical mechanisms of MTX.
Keywords: Methotrexate, folic acid, induction, sulfotransferase, STa, AST-IV
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