Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Effect of Folic Acid on Methotrexate Induction of Sulfotransferases in Rats

Author(s): Sangita Maiti Dutta, Smarajit Maiti, Guangping Chen.

Abstract:

Our earlier investigation showed that MTX is an inducer of rat and human sulfotransferases. Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver. This is important for understanding the clinical mechanisms of MTX.

Keywords: Methotrexate, folic acid, induction, sulfotransferase, STa, AST-IV

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2008
Page: [115 - 119]
Pages: 5
DOI: 10.2174/187231208784040997
Price: $58