Abstract
Embryonic stem cells (ESC) are a source of renewable cells, which possess a phenomenal potential to differentiate into a myriad of cell types. Thus, ESCs offer a potentially unlimited supply of cells, which can be deployed in developing cell-based therapies. The in vitro differentiation capacity of ESC into derivatives of the neuronal lineage has been demonstrated and the functionality of the ESC derived neuroprogenitors, upon transplantation into in vivo models has been substantiated. In this review, we discuss various approaches to directing ESC towards neural lineages and protocols for sorting and selection of differentiated progenies. We examine in particular in vitro differentiation of ESC to mid-brain dopaminergic (DA) neurons and glial cells and the potential issues related to the transition to the clinic.
Keywords: Human embryonic stem cells, Human embryonic stem cells, neuroprogenitors, neuroprogenitors, transplantation, transplantation, Parkinson's disease, Parkinson's disease, spinal cord injury, spinal cord injury
CNS & Neurological Disorders - Drug Targets
Title: Stem Cells for the Treatment of Neurological Disorders
Volume: 7 Issue: 1
Author(s): Mahendra S. Rao, Aparna Khanna, Soojung Shin and Soojung Shin
Affiliation:
Keywords: Human embryonic stem cells, Human embryonic stem cells, neuroprogenitors, neuroprogenitors, transplantation, transplantation, Parkinson's disease, Parkinson's disease, spinal cord injury, spinal cord injury
Abstract: Embryonic stem cells (ESC) are a source of renewable cells, which possess a phenomenal potential to differentiate into a myriad of cell types. Thus, ESCs offer a potentially unlimited supply of cells, which can be deployed in developing cell-based therapies. The in vitro differentiation capacity of ESC into derivatives of the neuronal lineage has been demonstrated and the functionality of the ESC derived neuroprogenitors, upon transplantation into in vivo models has been substantiated. In this review, we discuss various approaches to directing ESC towards neural lineages and protocols for sorting and selection of differentiated progenies. We examine in particular in vitro differentiation of ESC to mid-brain dopaminergic (DA) neurons and glial cells and the potential issues related to the transition to the clinic.
Export Options
About this article
Cite this article as:
Rao S. Mahendra, Khanna Aparna, Shin Soojung and Shin Soojung, Stem Cells for the Treatment of Neurological Disorders, CNS & Neurological Disorders - Drug Targets 2008; 7 (1) . https://dx.doi.org/10.2174/187152708783885183
DOI https://dx.doi.org/10.2174/187152708783885183 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Interfacial Effects on the Conformation of Amyloid-Beta Peptide
Protein & Peptide Letters Metabolomics and the Diagnosis of Human Diseases -A Guide to the Markers and Pathophysiological Pathways Affected
Current Medicinal Chemistry Recent Updates on the Association Between Alzheimer’s Disease and Vascular Dementia
Medicinal Chemistry Depressive Illness and Emotional Learning
Current Medical Imaging Apoptosis Induction by Ultrasound and Microbubble Mediated Drug Delivery and Gene Therapy
Current Molecular Medicine Experimental Animal Models of Myocardial Damage in Regenerative Medicine Studies Involving Adult Bone Marrow Derived Stem Cells: Ethical and Methodological Implications
Cardiovascular & Hematological Disorders-Drug Targets Rheumatic Manifestations in Malignancy
Current Rheumatology Reviews Detailed Molecular Understanding of Agonistic and Antagonistic Vitamin D Receptor Ligands
Current Topics in Medicinal Chemistry Safety and Efficacy of Levetiracetam for the Management of Levodopa- Induced Dyskinesia in Patients with Parkinson’s Disease: A Systematic Review
CNS & Neurological Disorders - Drug Targets Nuclear Medicine: Proof of Principle for Targeted Drugs in Diagnosis and Therapy
Current Pharmaceutical Design Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence
Current Neuropharmacology Lipid Composition of Cell Membranes and Its Relevance in Type 2 Diabetes Mellitus
Current Diabetes Reviews Modulation of Response to Audiovisual Stimuli Presented Peripherally by Visually Cued Endogenous Temporal Attention: An Event-Related Potentials Study
Neuroscience and Biomedical Engineering (Discontinued) Role of Neurotrophic Factors in Parkinson's Disease
Current Pharmaceutical Design The Role of Autophagy: What can be Learned from the Genetic Forms of Amyotrophic Lateral Sclerosis
CNS & Neurological Disorders - Drug Targets Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia
Current Neuropharmacology Neurobehavioral and Cognitive Changes Induced by Hypoxia in Healthy Volunteers
CNS & Neurological Disorders - Drug Targets Pathophysiology of Status Epilepticus Induced by Pilocarpine
Central Nervous System Agents in Medicinal Chemistry Role of Diagnostic Ultrasound in Patient Selection for Stroke Intervention
Recent Patents on CNS Drug Discovery (Discontinued) Remodeling of Protein Aggregates by Hsp104
Protein & Peptide Letters