Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes

Author(s): Christa Kneip, Rolf Terlinden, Horst Beier, Genfu Chen.

Abstract:

The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.

Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2008
Page: [67 - 75]
Pages: 9
DOI: 10.2174/187231208783478434