Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap

Author(s): Yohannes Teffera, Daniel J. Waldon, Adria E. Colletti, Brian K. Albrecht, Zhiyang Zhao.

Abstract:

High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a benzyl-S-glutathione conjugate and 2-(2,6-dichlorophenylamino) benzoic acid. A mechanism for the bioactivation of diclofenac involving decarboxylation is proposed.

Keywords: glutathione adduct, DPABA, diclofenac decarboxylation, Bioactivation pathway, Reconstructed ion chromatogram

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2008
Page: [35 - 40]
Pages: 6
DOI: 10.2174/187231208783478506