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Drug Metabolism Letters

Editor-in-Chief

ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Phenotyping of Cytochrome P450 3A Enzyme in Gujarat Population

Author(s): Ashutosh J. Jani, Shivprakash Rathnam and Anita A. Mehta

Volume 2, Issue 1, 2008

Page: [5 - 10] Pages: 6

DOI: 10.2174/187231208783478416

Price: $65

Abstract

CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.

Keywords: Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4


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