Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Phenotyping of Cytochrome P450 3A Enzyme in Gujarat Population

Author(s): Ashutosh J. Jani, Shivprakash Rathnam, Anita A. Mehta.

Abstract:

CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.

Keywords: Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2008
Page: [5 - 10]
Pages: 6
DOI: 10.2174/187231208783478416