Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

Author(s): Yunsheng Hsieh, Jiwen Chen, Ian Knemeyer, Lee Crossman, Walter A. Korfmacher.

Abstract:

The aim of this article is to focus on the implementation and the application of matrix-assisted laser desorption/ ionization-imaging mass spectrometric system (MALDI-IMS) to determine the disposition or biotransformation pathway of terfenadine and its active metabolite, fexofenadine in mouse and rat whole-body tissue sections. Whole-body MALDI-IMS data showed that the poor oral bioavailability of terfenadine was largely due to high first-pass metabolism in the intestines and the liver before the compound reached systemic circulation.

Keywords: Imaging mass spectrometry, MALDI, first-pass metabolism

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2008
Page: [1 - 4]
Pages: 4
DOI: 10.2174/187231208783478461