Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

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Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease

Author(s): Jose Luis Lopez, Jose Bermudez-Crespo.

Abstract:

Because of the multifactorial nature of many diseases, two-dimensional electrophoresis is a basic proteomics tool for its ability of simultaneously detecting post-and co-translational modifications, which cannot be predicted from genome sequences. This review describes the central role of proteomics tool, two-dimensional electrophoresis for clinical biomarker discovery, the identification of prognostic and diagnostic markers, their use in monitoring the effects of drug treatments and eventually finding more efficient and safer therapeutics for a wide range of pathologies.

Keywords: Proteomics, two-dimensional electrophoresis, biomarker discovery, drug discovery, clinical applications

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [187 - 197]
Pages: 11
DOI: 10.2174/157016407783221259
Price: $58