In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes

Title: In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes

Volume: 1 Issue: 4

Author(s): Eric C.Y. Chan and Lee-Sun New

Affiliation:

Keywords: Leflunomide, A77-1726, microsomes, metabolic profiling, UPLC, QTOFMS

Abstract: Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated α-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.

Cite this article as:

Chan C.Y. Eric and New Lee-Sun, In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes, Drug Metabolism Letters 2007; 1 (4) . https://dx.doi.org/10.2174/187231207783221402