Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites

Author(s): Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett, Rudolf Lucas.

Abstract:

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Keywords: Nostoc, ARDS, endothelium, ICAM-1, Interleukin 8, wound-healing

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2007
Page: [254 - 260]
Pages: 7
DOI: 10.2174/187231207783221385
Price: $58