Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Modelling and Measuring Redox Cycling and Cytotoxicity of Quinones

Author(s): Louise Hughes, Jordana Wingate, Renate Griffith, R. John Aitken.

Abstract:

The roles of alkylation and redox cycling in quinone toxicity were investigated. In general the more cytotoxic quinones produced the highest responses in an assay monitoring redox activity. No evidence of alkylation of high molecular weight protein thiols was detected. We conclude quinone toxicity is dominated by redox cycling.

Keywords: Structure-activity relationships, quinone toxicity, alkylation, redox cycling

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2007
Page: [245 - 253]
Pages: 9
DOI: 10.2174/187231207783221457
Price: $58