CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Stephen D. Skaper  
Department of Pharmaceutical and Pharmacological Sciences
University of Padova
Padova
Italy

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Neurogenesis and Stroke

Author(s): David A. Greenberg.

Abstract:

Stroke stimulates neurogenesis in select regions of the adult brain, and the newborn neurons that result can migrate to areas of ischemic injury, where they may have the capacity to enhance brain recovery. These observations suggest that stroke-induced neurogenesis may contribute to endogenous brain repair after stroke, and that the mechanisms that underlie neurogenesis may represent potential therapeutic targets. Alternatively, transplantation of exogenously derived neural cells might also be an approach to the treatment of stroke.

Keywords: Stroke, ischemia, neurogenesis, proliferation, migration, differentiation

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Article Details

VOLUME: 6
ISSUE: 5
Year: 2007
Page: [321 - 325]
Pages: 5
DOI: 10.2174/187152707783220901
Price: $58