The Sodium Pump: Bridging the Basic and Clinical Cardiovascular Sciences
Donald M. Foster,
Suresh K. Verma,
John C. Reneau,
David E. Dostal.
Year 2007 is the golden anniversary for the discovery of the sodium- and potassium adenosine triphosphatase, i.e., Na+, K+-ATPase, or Na+-pump by Jens Skou who shared the 1997 Nobel Prize in Chemistry for his discovery. Prior to identification of the enzymatic basis of Na+ and K+ active transport by Skou, the physiological and pharmacological manifestations of such a system had long been evident. Since 1957, there has been a dramatic increase in the knowledge of the physical, chemical, and kinetic properties of the pump and recognition of its basis for a wide range of physiological, pathological, and pharmacological aspects of the cardiovascular system. The Na+-pump has recently been identified as a key partner in a wide array of cell signaling pathways related to hypertrophy and expression of its marker genes. Taken together, these facts make it evident that the pump is a prime target for pharmacological interventions of cardiovascular diseases such as hypertrophy, hypertension, congestive heart failure (CHF), and preeclampsia. This review couples basic attributes of the Na+-pump with pathophysiological etiologies and clinical management of cardiovascular related maladies, and also discusses related patents.
Keywords: Cardiac glycosides, ouabain, marinobufagenin, Na+, K+-ATPase, sodium pump, signal transduction
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