Current Medicinal Chemistry - Central Nervous System Agents

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In Vitro Models of the Blood-Brain Barrier: When to Use Which?

Author(s): A(Bert). G. de Boer, P. J. Gaillard.

Abstract:

In this paper the various BBB systems have been described including the various isolation procedures of brain capillary endothelial cells (BCEC), the culture of monolayers of BCEC and endothelial cell lines, and the coculture of BCEC with various types of astrocytes. The transference of results between BBB culture systems has been discussed together with the application of the various BCEC co-culture systems in research. It is concluded that there is a need for interlaboratory validation of BBB data, particularly BBB transport data.

Keywords: Blood-Brain Barrier, BBB Cultures

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2002
Page: [203 - 209]
Pages: 7
DOI: 10.2174/1568015023358012
Price: $58