Current Drug Targets - Cardiovascular & Hematological Disorders

Garry X. Shen
University of Manitoba
Winnipeg, MB


Ca2+-Dependent Signaling Pathways in the Heart: Potential Drug Targets for Cardiac Disease

Author(s): Jeffrey Lynch, Marek Michalak.


Ca2+ is an important secondary messenger and any alteration to intracellular Ca2+ signaling pathways or components of these pathways can have a profound physiological effect on any cell, particularly cardiomyocytes. Early approaches to investigate heart disease focused on many muscle proteins, however recent findings indicate that molecules considered as “non-muscle” proteins may be equally important players in etiology of many cardiac pathologies. Many of these “non-muscle” proteins play a role in Ca2+ cycling or Ca2+-dependent signaling pathways in the heart. In this review we focus on Ca2+ -dependent pathways in normal, growing, and diseased hearts. Understanding of these unique signaling pathways may hold answers to many cardiac pathologies in children and adults.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2002
Page: [1 - 11]
Pages: 11
DOI: 10.2174/1568006023337853