Current Medicinal Chemistry - Central Nervous System Agents

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Non Peptidic CCK-2 (Formerly CCK-B) Antagonists: A Five Years Overview

Author(s): Anna Maria Capelli, Daniele Donati, Fabrizio Micheli.

Abstract:

Cholecystokinin (CCK) receptors are divided into CCK-1 (formerly CCK-A) and CCK-2 (formerly CCK-B) sub-types. CCK is a widely distributed neuropeptide in the brain and is considered a central nervous system transmitter. Possible therapeutic applications for CCK-2 antagonists include panic, anxiety, analgesia, schizophrenia, gastric disorders, and gastrointestinal tumours. This review covers the last five years findings in the field of such molecules

Keywords: cck-2 antagonists, cck-b antagonists, cholecystokinin, neuropeptide, panic,analgesic, schizophrenia,anxiety

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2002
Page: [287 - 294]
Pages: 8
DOI: 10.2174/1568015023357842
Price: $58