Anti-MRSA Cephems: An Update

Author(s): Dane M. Springer.


A review of recent developments in the field of anti-MRSA cephems is presented. The R.W. Johnson / Microcide collaboration seems to be the most advanced effort to date, but many other companies are continuing their efforts to develop a cephalosporin for use against serious Gram-positive infections such as MRSA. A detailed account of the progression of the MRSA cephem program at Bristol-Myers Squibb is provided. This work produced a number of compounds that had excellent biological activity, and were safe in a murine model of acute toxicity.

Keywords: anti-mrsa cephem, mrsa cephem

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2002
Page: [269 - 279]
Pages: 11
DOI: 10.2174/1568012023354929
Price: $58