Current Medicinal Chemistry - Anti-Cancer Agents

Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


Protein-Protein Interactions: Lessons Learned

Author(s): S. K. Sharma, T. M. Ramsey, K. W. Bair.


Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.

Keywords: Protein-Protein Interactions, Hydrophobic Interactions, Tyrosine Kinase Receptors, Calmodulin, histocompatibility complex, ADP-ribosylation factor

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Article Details

Year: 2002
Page: [311 - 330]
Pages: 20
DOI: 10.2174/1568011023354191
Price: $58