Protein-Protein Interactions: Lessons Learned
S. K. Sharma,
T. M. Ramsey,
K. W. Bair.
Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.
Keywords: Protein-Protein Interactions, Hydrophobic Interactions, Tyrosine Kinase Receptors, Calmodulin, histocompatibility complex, ADP-ribosylation factor
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