This non-nucleoside reverse transcriptase inhibitor review covers the patent and published literature from January, 1998-August, 2001. Major advances have been made in the past decade in discovering non-nucleoside reverse transcriptase inhibitors that are effective in inhibiting replication of wild-type virus. Attention is now focused upon the discovery of agents that are effective in inhibiting replication of virus with singly and doubly mutated HIV-1 reverse transcriptase. Notable advances in the discovery of such broad spectrum therapeutics are SG-153 and the quinazolines DPC961 and DPC083. Attempts at discovering other broad spectrum anti-viral agents are presented herein.
Keywords: Hiv-1 non-nucleoside reverse transcriptase inhibitor, nnrti, stavudine
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