Role of Fas-Ligand Induced Apoptosis in Pulmonary Inflammation and Injury

Author(s): George A. DosReis, Valeria M. Borges.

Journal Name: Current Drug Targets - Inflammation & Allergy

Volume 2 , Issue 2 , 2003

Abstract:

In the lung, inflammation followed by the loss of epithelial cell precursors beyond a safeguard threshold, leads to increased mesenchymal repair and autonomous fibrosis. Fas-Fas ligand induced apoptosis promotes IL-1β secretion, neutrophil extravasation, and loss of epithelial cells. In models of lung disease, inflammation and fibrosis can be controled by interfering with either Fas-Fas ligand interaction, or with downstream caspase activation. These results suggest that the Fas-Fas ligand pathway is a target for the design of new therapeutic strategies for lung diseases.

Keywords: apoptosis, fas, inflammation, macrophage, lung, fibrosis, cell death, chemokines

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2003
Page: [161 - 167]
Pages: 7
DOI: 10.2174/1568010033484287
Price: $58

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