Probiotics and Immune Regulation of Inflammatory Bowel Diseases

Author(s): Yingzi Cong, Astrid Konrad, Nuzhat Iqbal, Charles O. Elson.

Journal Name: Current Drug Targets - Inflammation & Allergy

Volume 2 , Issue 2 , 2003

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Intestinal microflora play an important role in the pathogenesis of inflammatory bowel diseases (IBD). Certain probiotic bacteria provide beneficial effects for human health and intervention of IBD. Possible mechanisms underlying these effects are diverse and include many aspects of the interaction of the host with its commensal microflora, with immunological and non-immunological effects. This review paper will focus on the recent progress in the use of probiotics in the treatment of IBD, and discuss the potential immunological mechanisms underlying their effects, such as the modulation of mucosal T cell, B cell, epithelial cell, dendrtic cell, macrophage, nature killer cell, antibody, and cytokine responses.

Keywords: probiotics, inflammatory bowel diseases, immune regulation, microflora., mucosa

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Article Details

Year: 2003
Page: [145 - 154]
Pages: 10
DOI: 10.2174/1568010033484278
Price: $58

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