Current Drug Targets - Inflammation & Allergy

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany

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Macrophage-Derived IL-18 Targeting for the Treatment of Crohns Disease

Author(s): Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura, Mamoru Watanabe.

Abstract:

Crohns disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohns disease. We here focus on the role of macrophages, especially macrophagederived IL-18 in both patients with Crohns disease and a murine model of Crohns disease.

Keywords: crohns disease, proinflammatory cytokines, il-18, immunotoxin, targeting

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2003
Page: [131 - 136]
Pages: 6
DOI: 10.2174/1568010033484250
Price: $58