Interleukin-5, Eosinophilic Diseases and Therapeutic Intervention

Author(s): Lennart Zabeau , Philippe Gevaert , Claus Bachert , Jan Tavernier .

Journal Name: Current Drug Targets - Inflammation & Allergy

Volume 2 , Issue 4 , 2003

Abstract:

Interleukin 5 (IL-5) is the key cytokine in an eosinophils life span: it supports eosinophilopoiesis and eosinophil differentiation, contributes to eosinophil migration, tissue localisation and function, and prevents eosinophil apoptosis. Given the likely role of eosinophils in chronic inflammatory diseases, a lot of research over the past decade was aimed at antagonising IL-5 function. It appears from recent studies that, although this can easily be achieved in vitro, blocking IL-5 function in vivo is much more difficult than originally anticipated. Here, we review the current status of IL-5 and IL-5 receptor research, with emphasis on strategies to interfere with IL-5 function.

Keywords: interleukin-5, eosinophilic diseases, eosinophil's life span, eosinophilopoiesis, eosinophil differentiation, inflammatory diseases

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2003
Page: [319 - 328]
Pages: 10
DOI: 10.2174/1568010033484043
Price: $58