Appraisal of AβPP Transgenic Mice as Models for Alzheimers Disease Amyloid Cascade

Author(s): Alex E. Roher , Tyler A. Kokjohn .

Journal Name: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents

Volume 3 , Issue 1 , 2003

Abstract:

AβPP transgenic mice replicate some aspects of Alzheimers disease pathology. Despite some similarities, significant biochemical and physical differences exist between the amyloid deposits characteristic of transgenic animals and AD patients. These differences may account for the fact that the promising results obtained by amyloid vaccination of AβPP transgenic mice were not replicated in humans. Aβ is an evolutionarily-conserved molecule of unknown function. Future therapeutic strategies directed toward interfering with amyloid production should be implemented with caution.

Keywords: beta amyloid, alzheimer disease, transgenic mice, therapeutic intervention, amyloid precursor protein, senile plaque, immunization, post-translational modification

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2003
Page: [85 - 90]
Pages: 6
DOI: 10.2174/1568013033358590

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